A new scientific study suggests that as little as 10 minutes of vigorous physical activity may play a significant role in slowing cancer progression. Researchers found that short, high-intensity workouts can change the molecular profile of the bloodstream, creating conditions that help curb bowel cancer cell growth and accelerate DNA repair.
The study, conducted by researchers at Newcastle University and published in the International Journal of Cancer, provides fresh evidence on how exercise influences cancer at a genetic and molecular level.
How Exercise Changes the Bloodstream
The researchers observed that after a brief session of intense exercise, the blood showed elevated levels of several small molecules. Many of these compounds are known to reduce inflammation, support blood vessel health, and improve metabolic function.
When bowel cancer cells were exposed in laboratory conditions to blood enriched with these exercise-induced molecules, the effects were striking. More than 1,300 genes changed their activity, influencing key processes such as DNA repair, energy production, and cancer cell proliferation.
These findings demonstrate that exercise sends powerful molecular signals through the blood, which can directly regulate genes involved in tumour growth and genetic stability.
Why This Matters for Bowel Cancer
Bowel cancer, also known as colorectal cancer, can occur anywhere in the large bowel, including the colon and rectum. Although it is more common in older adults, cases among younger people are rising. Early detection greatly improves treatment outcomes, making prevention strategies increasingly important.
The study adds to growing evidence that regular physical activity can reduce bowel cancer risk by around 20 per cent. Importantly, the benefits are not limited to long or intense workout routines.
Key Insights From the Researchers
Dr Sam Orange, Senior Lecturer in Clinical Exercise Physiology at Newcastle University and lead author of the study, explained the broader significance of the findings:
“What’s remarkable is that exercise doesn’t just benefit healthy tissues. It sends powerful signals through the bloodstream that can directly influence thousands of genes in cancer cells.”
He added that these insights could help scientists develop future therapies that mimic or enhance the biological effects of exercise, potentially improving cancer treatment and patient outcomes.
The team also found that exercise boosted genes linked to mitochondrial energy production, improving oxygen use within cells. At the same time, genes responsible for uncontrolled cell division were suppressed, which may help limit cancer cell aggressiveness. Post-exercise blood samples also showed improved DNA repair through activation of the crucial PNKP gene.
Study Details and What’s Next
The study involved 30 healthy but overweight or obese participants, aged between 50 and 78, a group considered at higher risk for cancer. Each participant completed a 10-minute high-intensity cycling session.
Researchers analysed 249 proteins in blood samples, finding that 13 increased after exercise, including interleukin-6 (IL-6), a protein known to play an important role in DNA repair.
Dr Orange, who also works at The Newcastle upon Tyne Hospitals NHS Foundation Trust, emphasised that even minimal effort counts:
“Even a single workout can make a difference. One bout of exercise, lasting just 10 minutes, sends powerful signals to the body.”
The research team now plans to explore whether long-term, regular exercise produces sustained benefits and how these effects might interact with chemotherapy or radiation therapy.
Exercise Beyond the Gym
The researchers stress that physical activity doesn’t have to involve gyms or sports. Walking or cycling for commuting, gardening, and household chores can all contribute to better health and lower cancer risk.
Disclaimer: This content is for informational purposes only and does not substitute professional medical advice. Always consult a qualified healthcare provider for diagnosis or treatment.